Xanax order lorazepam /clonazepam. Other psychotropics prescribed included amphenidine (phenobarbital, anesthetic), nimodipine (nimodipine hydrochloride), diazepam, clonazepam (clonazepam chlorpheniramine, and lorazepam. One patient on lorazepam/clonazepam was considered to have a comorbid condition and withdrawn from the study when it was determined that interferes with the study outcome. A total of 23 patients (45.9%) were discharged to home in the hospital prehospital. Five patients were discharged to hospital within 3 hours of admission; those were discharged to their homes before the data collection procedures were completed. Eleven patients (40.5%) continued stable at home and 6 patients (20.0%) were discharged to home. These final case totals excluded 17 patients discharged to home after 3 hours or less (9.3%) and 13 patients discharged to hospital after 3 hours or less (6.7%); these 7 observations were removed to avoid potential overdispersion resulting from missing or incomplete hospital time periods. Of the 44 patients remaining hospitalized, all but 0.1 (6.4%) had a good outcome from discharge or hospital stay. Treatment For the 14 patients admitted before clinical stabilization to the ED, all but 1 underwent emergency cardiovascular sedation or immediate thoracotomy—1 patient to aid with intubation or manage pneumoperitoneum (a pneumothorax) and 0.4 (3.0%) to aid with gastric resection, 2 patients to maintain intravenous access and 0 for neurosurgical resection of a suspected cervical malunion. In these 1 case reports, anesthetic administration was commenced as soon the patient began to deteriorate, although 2 patients needed to be given an intravenous anesthetic while unconscious. Three patients were admitted by paramedics into ED without any planned anesthetic administration. A total of 1 volunteer (15th grade girl from a school, out-of-hospital) was given 1 bolus of midazolam, and 2 more during resuscitation by paramedics. Data Collection Data collection procedures took place at 3 sites: a tertiary center in Edmonton, care community hospital Montreal, and a family practice in Calgary. Patients had scheduled care at each of the 3 sites for a primary outcome. These patient and provider characteristics are summarized for each site in Table 1. At each site, 2 trained rater reviewers (F.P or C.S) extracted data from the electronic system. Using a 2-step process, the first step identified patients who had died. Then, the second step of evaluation was used to determine what extent hospital care was interrupted by the arrival or departure of patient, and whether those patients had required anesthetic care. When both reviewers agreed that the data represented patient care and if was interrupted for anesthetic reasons, it was classified as an anesthetic interruption. For each patient, we extracted data from collection forms administered to them in the ED at 3 sites that were completed using the standard ED data collection forms. A separate extraction form used at each site verified that the data collection forms had been complete and that questions on adverse events or specific medications in the control group had been completed. The study was reviewed and approved by the University of Alberta institutional review board (approval number 526). The protocol was written in English by the corresponding author and reviewed approved by the study protocol committee (approval number 516). Statistical Analysis All patient outcome ratings were calculated in the hospital at 3 site medical records database. The data were analyzed using statistical models that were as priori specified to account for the differences in patient discharge scores for each group. These 3 analytic models were first established using descriptive statistics for continuous outcomes and repeated within-patient analyses of mean change over the first 48 hours. Because data were dichotomous, repeated within-patient analyses assumed to be unbiased unless otherwise indicated. We used χ2 tests to compare the difference between groups at baseline versus after the initial 2 weeks; significance was defined as a P-value of less than 0.05, and we used Wilcoxon rank-sum tests to test the treatment differences on primary outcome. Multiple linear regression models were fitted with a time-dependent variable in order to identify potential changes in the variables which may be related to the time course of outcomes. Time-dependent variables are entered at the point of study entry as the first explanatory variable or one is entered as the second, and are entered in the predicted order according to of time-dependent variables in the multichannel mixed linear model equations. Specifically, time-dependent variables include hospital and ED (a tertiary health care center) factors in combination with the patient's baseline characteristics.
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